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Targets Recommended: DHFR

1

抑制剂 & 化合物

3

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T15827 LY 345899

DHFR Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
LY 345899 是叶酸的类似物,也是亚甲基四氢叶酸脱氢酶 (MTHFD1;DC301) 和MTHFD2抑制剂,其IC50值分别为 96 nM 和 663 nM,对MTHFD1的Ki=为 18 nM。

化合物

LY 345899
Cat.No: T15827
Synonym:
Target: DHFR
Cat. No. Product Name Species Expression System
TMPK-01242 MD2/LY96 Protein, Human, Recombinant (His)

MD-2,Ly-96,ESOP-1,Lymphocyte anti...

Human E. coli
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.07 kDa and the accession number is Q9Y6Y9-1.
TMPK-00632 MD2/LY96 Protein, Cynomolgus, Recombinant (His)

ESOP-1,LY96,Lymphocyte antigen

Cynomolgus E. coli
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 17.97 kDa and the accession number is B3Y6B0.
TMPY-03999 MD2/LY96 Protein, Mouse, Recombinant (hFc)

lymphocyte antigen 96,ESOP-1,MD2,MD-2

Mouse HEK293 Cells
LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activa...

重组蛋白

MD2/LY96 Protein, Human, Recombinant (His)
Cat.No: TMPK-01242
Species: Human
Expression System: E. coli
MD2/LY96 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00632
Species: Cynomolgus
Expression System: E. coli
MD2/LY96 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03999
Species: Mouse
Expression System: HEK293 Cells
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